Défense de thèse

Défense de thèse de Hughes JAMBO

Infos

Dates
Le 15 décembre 2023
Lieu
Amphithéâtre Jorissen, Institut de Pharmacie, B36
Voir la carte
Durée
2 heures
Horaires
15h30

Le vendredi 15 décembre 2023, Monsieur Hughes JAMBO, titulaire d'un Master en sciences pharmaceutiques, à finalité spécialisée en pratique officinale, conseil et suivi pharmaceutique et d’un Certificat de formation à la recherche en sciences biomédicales et pharmaceutiques, présentera l'examen en vue de l'obtention du grade de Doctorat en Sciences biomédicales et pharmaceutiques, sous la direction de Monsieur Philippe HUBERT et de Monsieur Eric ZIEMONS.

Cette épreuve consistera en la défense publique d'une thèse intitulée :

"Supercritical fluid chromatography hyphenated to mass spectrometry : A reliable tool for pharmaceutical quality control" 

 

Le Jury sera composé de :

Marianne FILLET (Présidente), Amandine DISPAS (Secrétaire), Karl FLEURY-FRENETTE, Davy GUILLARME (Univ. Genève), Cédric HUBERT, Philippe HUBERT, Pierre LEBRUN (Pharmalex Belgium), Debby MANGELINGS (VUB), Pierre-Yves SACRE, Eric ZIEMONS.

Résumé de la thèse

This thesis explored the potential of supercritical fluid chromatography hyphenated to mass spectrometry (SFC-MS) as an analytical tool for pharmaceutical quality control. It focused on developing, optimizing, and validating SFC-MS methods to address drug analysis challenges, including assays, impurities determination, and adulterant detection.

Recent advances in SFC technology for pharmaceutical quality control were first reviewed, discussing instrumentation, applications, and regulatory requirements. 

Then, a SFC-MS method for quality control of cannabis plants is presented, which aimed at detecting synthetic cannabinoids. The study demonstrated specificity, sensitivity and robustness for a wide range of substances.

Following, a generic SFC-MS methodology for vitamin D3 assay in oily formulations was developed, in line with green analytical chemistry principles. The study evaluated several drug products and food supplements and presented a complete quality control strategy.

Finally, a study focused on optimizing a SFC-MS method for determining vitamin D3 impurities in oily drug products is presented. SFC-MS parameters and sample preparation were optimized to maximize sensitivity and minimize and control matrix interferences.  Afterwards, method quantitative performances were evaluated.
The thesis highlighted the potential of SFC-MS as a valuable analytical tool for pharmaceutical quality control, demonstrating its sensitivity, efficiency, and adaptability to diverse industry challenges, contributing to the advancement of SFC-MS applications.

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