Le mardi 23 juin 2026, Madame Margaux NAVEZ, titulaire d'un sciences biomédicales à finalité approfondie et d’un Certificat de formation à la recherche en sciences biomédicales et pharmaceutiques, présentera l'examen en vue de l'obtention du grade de Doctorat en sciences biomédicales et pharmaceutiques, sous la direction de Monsieur Olivier DETRY et de Monsieur François JOURET.

Cette épreuve consistera en la défense publique d'une thèse intitulée : "Impact of Normothermic Perfusion enriched with Mesenchymal Stromal Cells on Renal Ischemia/Reperfusion Injury". 

Cette défense de thèse est intégrée au symposium "De la perfusion à la thérapie : l'avenir de la transplantation" .

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Le jury sera composé de :

Pauline ERPICUM (Présidente), Marc-Gilbert Lagny (Secrétaire), Frédéric BARON, Tom DARIUS (UCLouvain), Olivier DETRY, Nicholas GILBO, François JOURET, Clara STEICHEN (Univ. Poitiers).

Résumé de la thèse

Kidney transplantation from donors after circulatory death (DCD) is increasingly used to address organ shortage but remains associated with a higher risk of ischemia–reperfusion (I/R) injury, negatively impacting early graft function and long-term outcomes. Limiting I/R-related damage at the time of transplantation therefore represent a major clinical challenge. Mesenchymal stromal cells (MSCs) have shown immunomodulatory, cytoprotective, and pro-regenerative properties. Experimental studies in rodent models of renal I/R have demonstrated their ability to reduce ischemic injury, while clinical trials have confirmed their safety in kidney transplant recipients.

The first objective of this doctoral thesis was to develop and optimize a normothermic machine perfusion (NMP) model as a translational platform for kidney preservation and therapeutic intervention. Using this optimized model, the second objective was to determine whether the administration of bone marrow–derived MSCs during NMP could attenuate I/R injury in DCD kidneys compared with NMP alone. This hypothesis was investigated using two complementary paired preclinical ex vivo models: a large-animal DCD model based on pig kidneys and human DCD kidney grafts declined for transplantation. In both models, paired kidneys from the same donor were simultaneously perfused at 37 °C with an oxygenated, blood-based solution, with or without MSC supplementation, allowing direct comparison of treatment effects.